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PF-04620110

PF-04620110

品 牌 MCE
C A S 号 1109276-89-2
货 号 HY-13009
规 格 10mg
价 格(元) 1009.00
咨询优惠价
货号 规格 价格
HY-13009 10mg 1009.00
HY-13009 50mg 4039.00

产品说明


PF-04620110是口服活性的甘油二酯酰基转移酶-1(DGAT1)抑制剂,IC50为19 nM。



PF-04620110的生物活性


PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
IC50 value: 19 nM [1]
Target: DGAT1
PF-04620110 and imipramine (internal standard) were separated using a Hypersil Gold C18 column, with a mixture of acetonitrile and 10 mm ammonium formate (90:10, v/v) as the mobile phase. The ion transitions monitored in positive-ion mode [M + H](+) of multiple-reaction monitoring were m/z 397.0 → 260.2 for PF-04620110 and m/z 280.8 → 86.0 for imipramine. The detector response was specific and linear for PF-04620110 at concentrations within the range 0.05-50 μg/mL and the signal-to-noise ratios for the samples were ≥10 [2].

化学信息


分子量 396.44 储存条件 参考CoA中推荐的条件进行储存。
分子式 C₂₁H₂₄N₄O₄
CAS号 1109276-89-2
溶剂/溶解度 10 mM in DMSO

相关文献


[1]. Dow RL, et al. Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6122-5.
[2]. Lee KR, et al. Determination of PF-04620110, a novel inhibitor of diacylglycerol acyltransferase-1, in rat plasma using liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic studies. Biomed Chromatogr. 2013 Jul;27(7):846-52.