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BI605906

BI605906

品 牌 MCE
C A S 号 960293-88-3
货 号 HY-13019
规 格 2mg
价 格(元) 2333.00
咨询优惠价
货号 规格 价格
HY-13019 2mg 2333.00
HY-13019 5mg 3500.00
HY-13019 10mg 6000.00
HY-13019 50mg 18000.00

产品说明


BI605906是的一种新型的 IKKβ抑制剂, 抑制IKKβ, IC50值为380 nM。



BI605906的生物活性


BI605906, a novel inhibitor of IKKβ, inhibits IKKβ with an IC50 value of 380 nM when assayed at 0.1 mM ATP.
IC50 value: 380 nM
Target: IKKβ
in vitro: BI605906 is a novel pharmacological inhibitors of the IKK family, inhibits IKKβ with an IC50 value of 380 nM when assayed at 0.1 mM ATP. The only other protein kinase that was inhibited of over 100 tested, which included IKKα and TBK1, was the IGF1 (insulin-like growth factor 1) receptor (IC50=7.6 μM). In IKKα?/? MEFs, BI605906 not only prevents the phosphorylation of physiological substrates, such as p105 and RelA, but also the phosphorylation of the serine residues in IKKβ (Ser177 and Ser181) that trigger its activation.

化学信息


分子量 432.51 储存条件 参考CoA中推荐的条件进行储存。
分子式 C₁₇H₂₂F₂N₄O₃S₂
CAS号 960293-88-3
溶剂/溶解度 DMSO: ≥ 29 mg/mL

相关文献


[1]. Clark K, et al. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104.