欢迎进入昊鑫官网

电话订购 · 意见建议400-861-5108

CC-401

CC-401

品 牌 MCE
C A S 号 395104-30-0
货 号 HY-13022A
规 格 2mg
价 格(元) 930.00
咨询优惠价
货号 规格 价格
HY-13022A 2mg 930.00
HY-13022A 5mg 1395.00
HY-13022A 10mg 2511.00
HY-13022A 50mg 7440.00

产品说明


CC-401是第二代ATP竞争性JNK抑制剂,具有抗肿瘤活性。



CC-401的生物活性


CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity.
IC50 value:
Target: JNK
In vitro: JNK inhibition decreased cytochrome c release, caspase 3 activation (P<0.05), and lipid peroxidation (P<0.05). JNK inhibition also transiently blocked phosphorylation of c-Jun at 60 minutes after reperfusion (P<0.05) without affecting other MAPK signaling, including p-38 and Erk activation [1].
in vivo: In acute disease, CC-401 blocked JNK signaling and reduced proteinuria in the first 24 h. The transient neutrophil influx seen at 3 h of disease was not affected, however. Continued CC-401 treatment suppressed glomerular and tubulointerstitial damage usually seen at 14 days [2]. Administration of CC-401 to rats prior to bilateral renal I/R prevented acute renal failure and largely prevented tubular damage, leucocyte infiltration and upregulation of pro-inflammatory molecules. However, delaying CC-401 treatment until 1 h after reperfusion (after the peak of JNK activation) had no protective effect [3].

化学信息


分子量 388.47 储存条件 参考CoA中推荐的条件进行储存。
分子式 C₂₂H₂₄N₆O
CAS号 395104-30-0
溶剂/溶解度 10 mM in DMSO

相关文献


[1]. Uehara T, et al. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation. 2004 Aug 15;78(3):324-32.
[2]. Flanc RS, et al. A pathogenic role for JNK signaling in experimental anti-GBM glomerulonephritis. Kidney Int. 2007 Sep;72(6):698-708.
[3]. Kanellis J, et al. JNK signalling in human and experimental renal ischaemia/reperfusion injury. Nephrol Dial Transplant. 2010 Sep;25(9):2898-908.