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DAPT

DAPT

品 牌 MCE
C A S 号 208255-80-5
货 号 HY-13027
规 格 5mg
价 格(元) 515.00
咨询优惠价
货号 规格 价格
HY-13027 5mg 515.00
HY-13027 10mg 893.00
HY-13027 50mg 2727.00

产品说明


DAPT (GSI-IX) 是γ-secretase抑制剂,能降低Aβ40和Aβ42的水平,IC50分别为115和200 nM。



DAPT的生物活性


DAPT(GSI-IX) is an inhibitor of γ-secretase; DAPT causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo.
IC50 value:
Target: γ-secretase
Does not effect APPα and APPβ levels. DAPT blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation.

化学信息


分子量 432.46 储存条件 参考CoA中推荐的条件进行储存。
分子式 C₂₃H₂₆F₂N₂O₄
CAS号 208255-80-5
溶剂/溶解度 DMSO: ≥ 215 mg/mL

相关文献


[1]. El Mouedden et al (2006) Reduction in Abeta levels in Sprague Dawley rat after oral administration of the functional gamma-secretase inhibitor, DAPT: a novel non-transgenic model for Abeta production inhibitors. Curr.Pharmaceut.Des. 12 671.
[2]. Munnamalai V, Hayashi T, Bermingham-McDonogh O.Notch prosensory effects in the Mammalian cochlea are partially mediated by fgf20.J Neurosci. 2012 Sep 12;32(37):12876-84.
[3]. Zhou JX, Han JB, Chen SM, Xu Y, Kong YG, Xiao BK, Tao ZZ.γ-secretase inhibition combined with cisplatin enhances apoptosis of nasopharyngeal carcinoma cells.Exp Ther Med. 2012 Feb;3(2):357-361. Epub 2011 Dec 6.
[4]. Yuan YY, Zeng ZY, Chen JM.[Effect of DAPT on Proliferation and Apoptosis of Human Multiple Myeloma Cell Line RPMI8226].Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Jul;20(4):922-5.
[5]. Oikawa N, Goto M, Ikeda K, Taguchi R, Yanagisawa K.The γ-secretase inhibitor DAPT increases the levels of gangliosides at neuritic terminals of differentiating PC12 cells.Neurosci Lett. 2012 Sep 6;525(1):49-53. Epub 2012 Jul 31.