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GSK2879552

GSK2879552

品 牌 MCE
C A S 号 1401966-69-5
货 号 HY-18632
规 格 2mg
价 格(元) 850.00
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货号 规格 价格
HY-18632 2mg 850.00
HY-18632 5mg 1200.00
HY-18632 10mg 2000.00
HY-18632 50mg 7000.00
HY-18632 100mg 12000.00

产品说明


GSK2879552是组蛋白去甲基化酶LSD1口服活性不可逆抑制剂,具抗癌活性,临床1期。



GSK2879552的生物活性


GSK2879552 is an orally available, irreversible, inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity.
IC50 value:
Target: LSD1 inhibitor
Upon administration, GSK2879552 binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the dimethylated form of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor-suppressor genes. This may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. LSD1, overexpressed in certain tumor cells, plays a key role in tumor cell growth and survival.

化学信息


分子量 364.48 储存条件 参考CoA中推荐的条件进行储存。
分子式 C₂₃H₂₈N₂O₂
CAS号 1401966-69-5
溶剂/溶解度 10 mM in DMSO

相关文献


[1]. Mohammad HP, et al. A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC. Cancer Cell. 2015 Jul 13;28(1):57-69.