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Bay 11-7082 (Bay 11-7821)

Bay 11-7082 (Bay 11-7821)

品 牌 GeneOperation
C A S 号 19542-67-7
纯 度 ≥98%
货 号 INK1001
规 格 5MG
价 格(元) 459.00
咨询优惠价
货号 规格 价格
INK1001 5MG 459.00
INK1001 10MG 689.00
INK1001 50MG 2119.00
INK1001 100MG 3829.00

产品说明

产品描述:


BAY 11-7082选择性且不可逆地抑制TNF-α诱导的IκB-α磷酸化,从而降低NF-κB和粘附分子ICAM-1, VCAM-1和E-选择蛋白在人内皮细胞内的表达,IC50 值是5-10 µM。BAY 11-7082的抑制特性体内表现出抗炎症活性[1]。BAY 11-7082通过干扰NF-κB抑制蛋白IκB-α失活和间接抑制NF-κB(IC50≈10μM)表达的方式激活自杀性红细胞死亡[2]。体内接种肿瘤转移动物模型内使用BAY 11–7082明显降低结肠癌细胞移植功能,BAY 11–7082显著减少再粘附结肠癌细胞凋亡的这一特性使其很有希望成为预防结肠癌转移的候选药物[3]。BAY 11-7082通过非依赖性抑制NF-κB活性的方式选择性抑制巨噬细胞中NLRP3炎症小体的活化[4]。

化学特性:


Cas No.: 19542-67-7
分子量: 207.25
分子式: C10H9NO2S
纯度: >98%
同义名: Bay 11-7821, Bay 117821, Bay117821
化学名: (2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
外观: 固态晶体
溶解: 溶于DMSO (up to 100 mM)
保存:3年 -20℃粉状

使用浓度:


BAY 11-7082的具体使用浓度请参考相关文献,并根据自身实验条件(如实验目的,细胞种类,培养特性等)进行摸索和优化。

参考文献:


[1] Pierce et. al. Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J.Biol.Chem. 272:21096-21103 (1997).
[2] Ghashghaeinia M. et. al. The NFκB Pathway Inhibitors Bay 11-7082 and Parthenolide Induce Programmed Cell Death in Anucleated Erythrocytes. Cell Physiol Biochem 27:45-54 (2011).
[3] Scaife et. al. Nuclear factor κB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis. Cancer Res. 62:6870-6878 (2002).
[4] Juliana C. et. al. Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome. J Biol Chem. 26; 285(13): 9792–9802 (2010).
[5] Strickson, S. et. al. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem J. 451(3): 427–437 (2013).